We are making extraordinary progress in the fight against pediatric Acute Myeloid Leukemia (AML) and it’s thanks to your support. Over the past few years, we’ve achieved groundbreaking milestones through Project Stella, an initiative focused on transforming the treatment landscape for children battling this devastating disease. This remarkable progress has been made possible exclusively through private funds and foundation support, allowing us to fund crucial research and create real change for these children.

Our Key Milestones in Project Stella:

• $3.7 million raised through private donations to fund the identification of key targets in CBF-GLIS/RAM AML, which has opened the door to new treatments.

• Development of a promising antibody-drug conjugate targeting the unique FOLR-1 receptor, a major target in AML-RAM, which has shown incredible potential in preclinical studies.

• The creation of the first-ever promising therapy, FOLR-1 CAR-T, for rare forms of pediatric AML. This cutting-edge treatment is now being evaluated in clinical trials.

• The survival rate for pediatric AML has gone from a dismal 8% to the possibility of a potential cure in less than 5 years—a breakthrough that has never been seen before in the field.

Why Monthly Donations Are Crucial:  As we push forward in our mission to cure pediatric AML, consistent and reliable funding is essential to continue making progress. Monthly donations are the backbone of this effort because they allow us to sustain research and development in a predictable and ongoing way. Without steady support, critical projects and therapies risk losing momentum, and we cannot afford to let that happen.

Here’s Why Monthly Donations Are So Important:

1. Steady Funding for Research: Monthly donations provide the consistent funding we need to maintain laboratory operations, hire skilled research staff, and purchase the specialized equipment necessary for groundbreaking work like the development of FOLR-1 CAR-T and other therapies.

2. Sustained Focus on Critical Targets: The development of new therapies takes time. With monthly donations, we can continue focusing on key targets like CLEC2a, PRAME, and WT1, all of which hold immense potential for saving young lives. Without regular funding, these efforts could stall, and promising therapies might not reach the clinic when needed most.

3. Offsetting Cuts in NIH Funding: NIH funding, which has historically supported much of the research landscape, is facing potential cuts. Your monthly donation ensures that we won’t be reliant on fluctuating federal funding and can continue developing critical treatments like CAR-T therapies targeting CLEC2a and PRAME, which are vital for rare forms of pediatric AML.

4. Long-Term Impact on Patient Care: Ongoing funding allows us to not only conduct essential preclinical studies but also to move therapies into clinical trials, ultimately leading to life-saving treatments for children suffering from AML. These treatments can improve survival rates, which have already surged from a dismal 8% to the potential for a cure within just a few years.

5. Making a Lasting Difference: Monthly donations ensure that your gift has a long-lasting effect. By committing to a regular donation, you’re helping fund dedicated research that could change the trajectory of a child’s life forever, potentially offering them a future where AML is no longer a death sentence.

A Matching Gift Opportunity:  To make this effort even more impactful, we are thrilled to announce that an anonymous donor has committed $100,000 for this next campaign.  This means that your contribution, whether $25, $50, $100, or more, will be doubled, maximizing the effect of your support. Every dollar you donate will go twice as far, helping us fund vital research and development that could lead to cures for pediatric AML.

How You Can Help:  We understand that not everyone can contribute a large amount each month, but every contribution, no matter the size, makes a real difference. Here are some ways you can help:

Become a Monthly Donor:  By committing to a small monthly donation, you’re making a powerful, long-term impact. Even contributions of $25, $50, or $100 per month can make a lasting difference. Here’s how your monthly gift can help:

• $25 per month helps fund essential lab supplies.

• $50 per month supports critical research tools and equipment.

• $100 per month helps sustain vital lab positions and staff working on these innovative therapies.

And remember, with the matching gift, your $25 donation will be doubled to $50, your $50 donation will become $100, and so on.

One-Time Donation:  If a monthly commitment isn’t feasible, a one-time donation will still support the ongoing success of Project Stella.

Why Your Support Matters:  We’ve already made incredible strides toward curing pediatric AML. Thanks to you, survival rates have soared from 8% to the potential for a cure in less than 5 years. But to continue pushing forward, we need a consistent, reliable funding stream. Your commitment, whether monthly or a one-time donation, is essential to making this dream a reality for children and families who have suffered for far too long.

Together, we can continue to make groundbreaking advancements in pediatric cancer treatment and bring hope to families who need it most.

Donate Now and help us make history in the fight against pediatric AML with Project Stella for children lost to this devastating disease.

Thank you for your unwavering support.